new_n_lost
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Mutations in which of the following genes when inherited in the germline are least likely to be associated with the development of breast cancer?
A. ATM gene
B. bcl-2 gene
C. BRCA 1 gene
D. BRCA 2 gene
E. p53 gene
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| new_n_lost
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___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| new_n_lost
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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| keepgoing
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b??
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| new_n_lost
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BRCA 1 & BRCA 2 cause early breast cancer (dominant inheritance). ATM gene causes breast cancer ��" DNA repair disorder (recessive inheritance). P53 mutations are found in ~60% of all human cancer types including breast. Note Li-Frumeni syndrome ��" vulnerable to a wide range of cancers, 50% likelihood of Ca by age 30 & 90% by age 65. The precise function of p53 is unknown ��" may act as DNA policeman to prevent transcription & replication of unstable DNA.
Bcl-2 is involved in the control of apoptosis (programmed cell death) & prevents the p53 mediated destruction of cells with damaged DNA. It also may prevent the death of cells severely damaged by chemotherapy, & mediates drug resistance & contributes to neoplasia by this mechanism rather than promoting aberrant cell growth. It was first identified because of an association with follicular lymphoma.
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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