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Author7 Posts
  #1

where are the receptors for steroids located


a osteoclast
b osteoblast
c both


  #2

Osteclast.

I have come across a situation which gives a hypoestrogen state and asks your question.The role of RANK ligand on osteoclsts is srongly emphasized in bone resorption.You can get a detail explanation in High yield Histology which has some ambiguity .But given the situation I go only for Osteoclast..because you clearly stated Steroid.The same thing holds true for 1,25-(OH)2 vitamin D which acts on Osteoblasts to secrete IL-1 which again acts on Osteoclasts and Calcitonin which act on Osteoclasts and cause bone resorption.I think this is a good start for subsequent discussion and can come up with a conclusion.



  #3

hi sany......high yield says that the steroid hormones include the vitamin d which clearly acts on osteoblasts....but they havent mentioned specifically about the exogenous steroids (taken for adrenal insufficiency)receptors.....also i want to correct you that osteoBLAST have RANKL NOT RANK WHICH IS ON MACROPHAGES.......it is only when the RANKL AND RANK interact the macrophages become osteoclast...interesting hmmm......


  #4

Thank you..I am waiting to learn more.


  #5

eeshan is right


  #6

i doubt steroids have receptor on osteoClasts,,they have receptor on osteoblast and osteocyts (same as PTH) as far as i know only calcitonin has receptor on osteoClast and can Directly affect them ,the others can affect osteoclast indirectly via osteoBlasts

i am not sure thu ,please guys, share your ideas even something simple like this can be a question on exam .


  #7

Docs:

Answer is both.
Osteoclast apoptosis is regulated by estrogen.
Osteoblast differentiation is modulated by sex steroids.

---Dr. J. Iyer





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