new_n_lost
Forum Hero
Topics: 674
Posts: 6,150
|
Mannitol Given to him can cause Pulmonary Edema, which might be given to him bcos of Signs of ICP.
Butenamide n Spironlactone r used in Rx of Pulmonary Edema while chlorthalidone can cause Hyperosmolar Coma in a diabetic person which might lead to ARDS or Pulmonary Edema
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| me007
Forum Guru
Topics: 72
Posts: 799
|
correct.
again to the mannitol -in the brain it help water excretion from tissue to plasma, reducing edema and ICP. nothing connecting cerebral vessel constiction and mannitol i could find.
|
| new_n_lost
Forum Hero
Topics: 674
Posts: 6,150
|
Well from wht i have read is that Mannitol causes a marked dilution of blood which relatively causes the cerebral blood flow to increase n cerebral arteries constrict so that the there is a pressure autoregulation hence enhancing the fluid levels to decrease in the white matter tissue much in response to raised ICP. U will have to search for it cos it took me a long time to find exactly the answers its in old journals of Neurosurgery 1981*1985 but htey have mentioned this fact that Mannitol does induce cerebral vasoconstriction rather than the direct of its being a osmolar substance.
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| Ancylostoma
Forum Guru
Topics: 42
Posts: 637
|
usmle world says somthing about the vasoconstriction
|
| sixfeet
Forum Senior
Topics: 7
Posts: 164
|
Probably has 2 distinct effects in the brain:
Immediate plasma expanding effect. Reduces hct and blood viscosity. Increases cerebral blood flow and oxygen delivery causing autoregulatory vasoconstriction. Probable explanation for reduction in ICP within a few mins and why reduction is most marked in those with low CPP
Osmotic dehydration of brain. Delayed for 15-30 mins and persists for 90 mins to ≥6h
___________________
GOD BE MY SHEPHERD!!
|
|
| |
| | | | | |
