asmi
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a pt with metastatic prostate cancer may be treated with an agent such as leuprolide. Such medications work by which of the following mechanisms?
/ A. BIocking cytochrome P450
/ B. BIocking testicular androgen production
/ C. BIocking testosterone at the target tissue level
/ D. Directly blocking the adrenal gland synthesis of androgens
/ E. Indirectly suppressing LH and FSH secretion
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| mistral92
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E indirectly supressing FSH/LH ( by blocking GNRH)???
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| asmi
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correct
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| asmi
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These medications, known as GnRH agonists (e.g., leuprolide, nafarelin, goserelin, buserelin), work by activating the GnRH receptors in the pituitary gland. This creates an initial increase in the release of LH and FSH, causing an initial increase in testosterone ("flare phenomenon"). With time, there is down-regulation of the pulsatile release of LH and FSH, and ultimately, suppression of LH and FSH due to inhibition of the hypothalamic-pituitary axis. This leads to a decrease in testosterone levels. Castrate levels of testosterone are reached within 30 days.
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| mjl1717
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Great asmi!! also used for endometriosis
can cause hot flashes and impotence.
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| asmi
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thanks for the side effects mjl ....
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| asmi
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leuprolide can also be used in polycystic ovary syndrome and uterine fibroids.
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| usmleasr
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actions of leuprolide depends on whether u use it continously or intermittently...when u use intermittently...it increases LH & FSH..when used continuously it decreases ...LH & FSH 8)
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| asmi
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yes thats right 
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