new_n_lost
Politically InCorrect
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A 39-year-old female has fingers that are tapered and clawlike, with decreased motion at the small joints. The microscopic appearance of the skin is shown in the figure. She also has diffuse interstitial fibrosis of the lungs, with pulmonary hypertension and cot pulmonale. Which of the following dermal inflammatory cells is considered the most likely initiator of the process that results in her skin disease?
O (A) CD4 lymphocyte
O (B) Macrophage
O (C) Mast cell
O (D) Neutrophil
O (E) NK cell
Edited by new_n_lost on 03/12/07 - 06:02 AM
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| Luckyall
Forum Guru
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is it CD4 lympho ? im thinking Sjogren S.
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| obgyne2b
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A, but I think the problem is scleroderma, or rather, sclerodactyly (of CREST syndrome).
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| doc179
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yeah...scleroderma... I think...A
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| new_n_lost
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A) Although not proved, the CD4 lymphocytes are thought to respond to some unknown antigenic stimulation, releasing cytokines that further activate macrophages and mast cells. The result is extensive dermal fibrosis that produces the clinical appearance of sclerodactyly with scleroderma. Neutrophils and NK cells do not participate in this process. Despite scleroderma being an autoimmune disease, inflammation is minimal. The major finding is progressive fibrosis of skin, lung, and gastrointestinal tract.
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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