new_n_lost
Forum Hero
Topics: 674
Posts: 6,148
|
A 2-year-old girl was admitted to the hospital after she developed a severe infection of the large intestine. She had a history of recurrent infections and impaired wound healing. She was previously hospitalized at 3 weeks of age because of swelling and redness around the umbilical stump and high fever. Laboratory tests revealed a high white blood count, normal proportions of B and T lymphocytes and normal levels of IgM, IgG and IgA antibodies. However an additional test demonstrated a lack of migration of lymphocytes to the site of a localized skin abrasion. Furthermore, flow cytometric analysis revealed that relatively few of the child's blood lymphocytes reacted with a monoclonal antibody to CD18.
the most likely diagnosis :-
A) Leukocyte Adhesion Deficiency
B) Systemic Lupus Erythematosus
C) Hereditary Angioneurotic Edema
D) X-Linked Agammaglobulinemia
E) Severe Combined Immunodeficiency
F) X-Linked Hyper IgM Syndrome
G) Paroxysmal Nocturnal Hemoglobinuria
H) DiGeorge Syndrome
I) Wiskott-Aldrich Syndrome
J) Selective IgA Deficiency
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| doc179
Forum Guru
Topics: 67
Posts: 1,217
|
A
|
| indidoc1
Forum Guru
Topics: 51
Posts: 991
|
AAAA
___________________
"Whether you think you can or whether you think you can't, you're right!" ~ Henry Ford
|
| keepgoing
Forum Fanatic
Topics: 104
Posts: 2,236
|
looks like a
___________________
"You must feel confident enough within urself to follow your own dreams"If you think you can, you can.If you think you can't, you're right"
|
| new_n_lost
Forum Hero
Topics: 674
Posts: 6,148
|
A LAD involves an impairment in which neutrophils, monocytes and leukocytes are unable to adhere to vascular endothelial cells, thus preventing extravasation of these cells into tissue spaces. Also impaired are the abilities of CTLs and NK cells to adhere to their target cells and of helper T cells and B cells to form conjugates. LAD is due to defective biosynthesis of the b-chain component (CD18) of one subfamily of integrin adhesion molecules, that include CR3, CR4 (complement receptors), LFA-1, ICAM-1. The b-chain defect results in a near-total loss of all these membrane glycoproteins. Individuals with this defect manifest recurrent bacterial infections (high white blood count is an indication) and impaired wound healing.
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
|
| |
| | | | | |
