new_n_lost
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Active, durable immunization against poliomyelitis can be accomplished by oral administration of attenuated vaccine (Sabin) or by parenteral injection of inactivated (Salk) vaccine. These vaccines are equally effective in preventing disease because
A) both induce adequate IgA at the intestinal mucosa, the site of entry of the virus.
B) antibody in the serum protects against the viremia that leads to disease.
C) viral antigen attaches to the anterior horn cells in the spinal cord, preventing attachment of virulent virus.
D) both vaccines induce formation of interferon.
E) both vaccines establish a mild infection that can lead to formation of antibody.
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| me007
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b
a - only related to oral vac.
c - looks like pathophysiology of actual desease
d - INF is not protective for polyo
e - alive only oral, what can cause disease in immunodeficient pt.
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| indidoc1
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B.
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| doc179
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B
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| new_n_lost
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| new_n_lost
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B Both attenuated and inactivated vaccines lead to formation of circulating antibody, which would provide protection by intercepting the infecting virus before it reaches the target tissue in the central nervous system. While the Sabin vaccine induces mucosal gut IgA that may intercept virus at the portal of entry, the parenterally injected Salk vaccine is not effective in inducing mucosal IgA. Viral antigen in the vaccine might attach to the anterior horn cells in the nervous system, but it probably would not provide durable immunity. Induction of interferon would represent potentially only brief protection. Only the Sabin vaccine, being attenuated and ``live,'' would induce a mild infection.
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