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Author6 Posts
  #1

A 45-year-old homeless individual with known chronic schizophrenia. He appears to be generally malnourished with decreased temporal and proximal extremity muscle mass. Which of the following immunologic/hematologic abnormalities is most likely to be found in this situation?



A) Depressed absolute lymphocyte count
B) Depressed absolute monocyte count
C) Depressed absolute granulocyte count
D) Hypogammaglobulinema
E) Microcytic red cells


  #2

D) Hypogammaglobulinema

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  #3

C) Depressed absolute granulocyte count

  #4

It shud b hypogammaglobunemmia as there is generalized protein def.

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  #5

Ans A) Depressed absolute lymphocyte count


Nutritional assessment should be undertaken in any patient with a debilitating chronic illness or in homeless individuals. The conditions that promote involuntary diet restriction such as drug abuse, chronic alcoholism, or many psychiatric disorders are often associated with malnutrition. Severe malnutrition, defined as <70% of ideal body weight, causes diminution of skeletal protein and is evidenced by decreased temporal and proximal extremity muscle mass. Decreased body fat stores are indicated by a decrease in skin-fold thickness (the so-called pinch test). Evidence of vitamin deficiency may abound, including bruising due to vitamin C deficiency or coarse skin with "goose bumps" due to vitamin A deficiency. Vitamin deficiency can cause ophthalmoplegia, confabulation, cerebeller gait, and peripheral neuropathy. While levels of serum immunoglobulins, granulocytes, and monocytes are generally well preserved, lymphopenia, which can be promoted by chronic alcoholism or other chronic infections such as HIV, is the most common hematologic abnormality. Patients may often display anergy in skin testing. More common than the microcytic red cells in iron deficiency is the macrocytosis of coexistent vitamin B12 deficiency.

  #6

Well, the Q is confusing and incorrect... In the explanation, the lymphopenia is linked to "...chronic alcoholism or other chronic infections such as HIV..." but the Q itself does not describe that. In fact, dietary iron deficiency seen in many malnourished Pts can cause microcytic anemia

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