new_n_lost
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A 25-year-old male has a history of celiac disease. Several days after an upper respiratory infection, he notices dark red-brown urine that persists for the next 3 days. His urine then becomes clear and yellow, only to become red-brown again in a month. His 24-hour urine protein level is now 200 mg.
Which of the following alterations is most likely to be seen in the glomeruli on renal biopsy?
(A) Subepithelial deposits by electron microscopy
(B) Granular staining of the basement membrane by anti-IgG
(C) Mesangial IgA staining by immunofluorescence
(D) Diffuse proliferation and basement membrane thickening by light microscopy
(E) Thrombosis in the glomerular capillaries
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| Aashi
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(C) Mesangial IgA staining by immunofluorescence
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| Diego Casali
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"Glomerular IgA deposition occurs in up to a third of patients with gluten enteropathy.
Most of these patients have no clinical manifestations of the disease. However, IgA nephropathy and gluten hypersensitivity are associated, and withdrawal of gluten from the diet of these patients has resulted in clinical and immunological improvement of the renal disease."
From eMedicine
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| unique1
InGodITrust
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Yup... C.
lol , seems like Berger disease is hot these days 
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| new_n_lost
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The Reason Being most of the Guys n Gals who view the question dont answer Except the Forum Seniors who sometimes Stroll around in the Conquered Areas.
Honestly Unique the Co relation of Berger with Celiac Disease is Not Known Hence i Posted the Question.
lgA nephropathy, also known as Berger disease, can explain the presence of recurrent hematuria in a young adult. There is no nephrotic syndrome, and mesangial IgA deposition is characteristic. The initial episode of hematuria usually follows an upper respiratory infection. IgA nephropathy occurs with increased frequency in patients with celiac disease. Granular staining of basement membrane with IgG antibodies denotes immune complex deposition, as may occur in post infectious glomerulonephritis; these are seen as subepithelial deposits by electron microscopy.
Patients with these changes present with nephritic syndrome. Diffuse proliferation and basement membrane thickening denotes membranoproliferative glomerulonephritis. lgG and C3 are deposited in the glomeruliin this condition.
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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
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