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Patho Q

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5 Posts

epica

03/08/07 - 08:46 PM

A 36-year-old woman has noted increasing numbers of disfiguring nodular masses involving the skin of her trunk and extremities. She has experienced frequent headaches over the past month. On physical examination these 0.5 to 2 cm subcutaneous masses are firm and non-tender. MR imaging of the brain shows an ill-defined 4 cm mass of the right parietal lobe. An abdominal CT scan shows a 3 cm mass involving the left adrenal gland. Laboratory studies show increased urinary free catecholamines. No other family members are affected by these problems. A mutation involving which of the following genes is most likely to be present in this woman?

A APC

B CFTR

C K-RAS

D NF-1

E N-MYC

F TP53

G RB

new_n_lost
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03/08/07 - 09:31 PM

This is the most trickest i have encountered its NF1

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new_n_lost
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03/08/07 - 09:33 PM

Could also post the Explainations too for this one esp

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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."

epica

03/08/07 - 09:38 PM

D) CORRECT. She has neurofibromatosis type 1, which is associated with development of neoplasms including neurofibromas, schwannomas, gliomas, and pheochromocytomas. NF-1 is a tumor suppressor gene.

new_n_lost
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03/08/07 - 09:48 PM

Buddy I had to literally wreck my brains over it cos the only thing was bothering me was No family history so MEN r out of the Question Age rules out Neuroblastoma. I wasnt sure abt NF1 so i posted the answer then went to search over it the only thing which goes into favor of Neurofibromatosis is disfiguring masses. its a Very Vague Question

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FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."

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