indidoc1
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A renal biopsy is performed on a 33-year-old female
who has had increasing renal failure for the past week.
Which of the following changes seen with electron micros-
copy most likely suggests a diagnosis of acute tubular
necrosis?
(A)Mitochondrial swelling
(B) Plasma membrane blebs
(C) Chromatin clumping
(D) Nuclear fragmentation
(E) Ribosomal disaggregation from endoplasmic reticu-
lure
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| Ancylostoma
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D irreversible damage
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| indidoc1
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 Thanks ancy.. fr such a quick reply..
u really jumped onto that  ,..
But the prob is.. isn't ATN reversible mostly??
BTW,, ur ans is absolutely correct as far as the book is concerned.
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| indidoc1
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ok.. found an explanation fr this one.. kinda...
ATN occurs usually by ischemic change which quickly leads to irreversible cell injury (Which is asked here) leading to coagulative necrosis n sloughing off of the tubules...
The reversible nature is bcoz some cells stick in there n regenerate later on..
Thanks ancylostoma.
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| new_n_lost
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Ok Here r my 2 cents
Plasma Membrane Blebs n Mitochondrial Swelling r found in Less Severely Ischemic cells in ATN who r going to or abt to go undergo Apoptosis.
While Nuclear Fragmentation is the Last stage n confirms the diagnosis n Therefore representing Both Cell Death n Apoptosis in ATN.
Attached Files:
Apoptosis Schematic.doc (189 KB, 12 downloads)
Edited by new_n_lost on 03/04/07 - 05:30 PM
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| keepgoing
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necrosis---sign--->karyorrehexis(frag of nuclear) isnt it sufficent??
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| unique1
Biochemistry
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Necrosis = irreversible cell injury
and only cell fregmantaion (karyorrhexis) is a sign of irreversible injury among the choices. All others are reversible.
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