asmi
Forum Hero
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*cryptococcal meningitis ?
What is the MOA ?
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| dxtxpx
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For cryptococcal meningitis, the treatment of choice is amphotericin B plus flucytosine for 6 wk.
Fluconazole is also effective. It is less toxic, and oral and IV doses produce comparable peak plasma concentrations.
When CSF has been sterile 2 wk after initiation of amphotericin and flucytosine, the patient can be switched to fluconazole po (if renal function is normal) for at least 8 wk after the CSF became sterile. A maintenance dosage of po can prevent relapses (eg, in AIDS patients).
If cryptococcal meningitis is mild (as suggested by intact mental status, normal CSF pressure, and cryptococcal antigen < 1:1024), fluconazole po can be given as monotherapy for 10 to 12 wk.
Mechanism of action of Amphotericin B: binds ergosterol, forms membrane pores that allow leakage of electrolytes & disrupts homeostasis
Mechansim of action of Flucytosine: inhibits DNA synthesis by conversion to flurouracil, which competes with uracil
Mechanism of action of Fluconazole: Inhibits fungal steroid (ergesterol) synthesis
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| asmi
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U R PERFECT.. EXCELLENT
KEEP IT UP :idea:
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