asmi
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There is excess mineralocorticoid secretion in this syndrome....but B.P. will be normal.Why ,what is the reason ?
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| peekay
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IS IT DUE TO PRODUCTION OF WEAK MINERALOCORTICOIDS AND ALDOSTERON PRODUCTION IS LOW AND RENIN IS NOT AFFECTED.MAY BE I AM WRONG
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| asmi
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There is defect in chloride reabsorption in kidneys.
It is characterised by mineralocorticoid excess.
There is hypokalemia---->increased renin release--->increased angiotensin II and aldosterone--->increased renal kallekrein--->increased bradykinin --->increased synthesis of PG E2 and I 2 ...potent vasodilators.
Therefore the pt will have normal B.P. inspite of excess aldosterone secretion.
I hope this helps
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| peekay
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thanks for the quick review
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