docsergio2003
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Can someone correct me if I'm wrong, please?
Type of icterus Urine Feces
Hemolytic Dark Dark
Hepatic Dark Pale
Obstructive Pale Pale
Does any of u posess a better tabel, a more detiled one ???
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| mildus
Forum Guru
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Hemolytic icterus:
blood: indirect bilirubin is increased due to haemolysis;
urin: (urobilinogen increased since the liver doesn't have time to reuptake it from enterohepatic recirculation because there is much indirect bilirubin which waits to be uptaken, thus urobilinogen stays in blood and then comes into the kidney and goes to urine; there is no bilirubin in urine because indirect bilirubin isn't filtrable); feces: more dark (since more bilirubin is secreted into the bile)
Hepatic icterus
blood: both indirect and direct bilirubin are increased (damaged hepatocytes: more indirect bilirubin stays in blood, less it is transformed to direct bilirubin, direct bilirubin is less secreted and goes back to blood)
urine: since direct bilirubin is increased in the blood, it also appears in urine and makes it dark
feces: since no (or very little) direct bilirubin is secreted into bile ducts, feces becomes less dark or totally pale
Obstructive icterus:
blood: increased direct bilirubin since it regurgitates into hepatocytes and between them and goes to blood (since there is opstruction in bile ducts)
urine: dark due to direct bilirubin which is incresed in the blood and thus in urine
feces: pale
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| docsergio2003
Forum Newbie
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..thanks Mildus fo the reply..I definetely agree with the physiopathology..
so it's sth like this..
Type of icterus Urine Stool
Hemolytic Dark because of increased Urobilin(Ub) Dark because of Sb (Ubg it's colourless) no B in the U
Hepatic Dark because of CB, but Ub too, cause Pale because of de
enterohep circ is decreased so more creased Ubg in
Ubg is converted to the kidney where is gut to become Sbg
transformed to Ub
Cholestatic Dark because of CB, not Ub, cause it can Pale for the same not b formed in the gut because of the reason the urine
OBSTRUCTION
Question? ok so let's see if I'm right u never encounter pale urine, I mean in jaundice ???
and second does the colour of the urine differ when it is because of the excess of Ub, CB and Ub, or only CB? Does it have any relevance???
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| docsergio2003
Forum Newbie
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Hemolytic
Urine: Dark because of increased Urobilin(Ub);no B in the U
Stool ark because of Sb (Ubg it's colourless)
Hepatic
Uark because of CB, but Ub too, cause enterohep circ is decreased so more Ubg is converted to the kidney where is transformed to Ub
S:Pale because of decreased Ubg in gut to become Sbg
Cholestatic
Uark because of CB, not Ub, cause CB can not convert to the Ubg because of the OBSTRUCTION
S:Pale for the same not b formed in the gut because of the reason the urine
Questions? ok so let's see if I'm right u never encounter pale urine, I mean in jaundice ???
and second does the colour of the urine differ when it is because of the excess of Ub, CB and Ub, or only CB? Does it have any relevance???
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| mildus
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I think not
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| docsergio2003
Forum Newbie
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u'r not sure Mildus r u?
Anyway thanks for the reply !
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| new_n_lost
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well i think u can u wont find Pale urine in Jaundice no matter wht the cause cos Uncon Bili is never excreted n if there is dec urobilogen production as in Obs. Janudice then a pale will be found but then u have presence of Direct Bili which changes the color.
"There is urobilinogen in urine, but that is colourless and turns to the coloured urobilin oxidation product only very slowly. Complete blockage of the biliary tree removes urobilinogen from the urine but also adds bilirubin-glucuronide to urine, making the urine dark, perhaps even the colour of black tea."
Edited by new_n_lost on 03/12/07 - 06:36 PM
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| SmokyWaters
Forum Elite
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for docsergio2003
URINE stays DARK no matter whatever type it is
Secondly...clay colored or pale stools are in obstructive type.
NOT IN HEPATIC TYPE...unless and until hepatic type is so much destructive that it causes destruction of bile ducts and causes intrahepatic cholestatsis...
for clinically differentiating dark urine...whenever bile salts like in POST HEPATIC (cholestatic) jaundice is present....there is FROTH in urine and the urine tends to be darker as told by the person above me...
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| nandrolone
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hI GUYS
I THINK IT'S the urochrome pigment which imparts yellow color to urine Not unconjugated( unfilterable) nor urobilin(colourless)
Conj bilirubin would obviously make it darker
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| nandrolone
Forum Junior
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sorry, actually urobilinogen is colourless. urobilin is derived from urobilinogen on standing.... so basically on micturation its the urobilinogen that is excreted
qjmed.oxfordjournals.org/cgi/reprint/19/4/263.pdf
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