new_n_lost
Politically InCorrect
Topics: 654
Posts: 6,115
|
5. Hypotension. Bartter Syn, ????
And even if its not Bartter the Kid will still have hypotension his aldosterone levels will be increased n angiotension 2 receptors somethig might be wrong them but cant say for sure
Edited by new_n_lost on 02/16/07 - 09:05 AM
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| me007
Forum Guru
Topics: 72
Posts: 803
|
nor 4 neither 5.
but it is Bartter syndrome.
|
| unique1
InGodITrust
Topics: 19
Posts: 1,421
|
Then it should be A.
___________________
I can't change the direction of the wind, but I can adjust my sails to always reach my destination.
|
| new_n_lost
Politically InCorrect
Topics: 654
Posts: 6,115
|
lol , now this is interesting ok with the given information on Bartter which i have or i know for sure is that Bartter syn. pt will have hypokalemia, hypocholremia with metabolic acidosis with renin + aldosterone levels elevated. there is some Mutation in the NaCl & K Cl cotransporter in the loop of Henle so i really dont know where there is a co relation between Angiotensin II AT-1 receptor. so this is wht i know ??
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| me007
Forum Guru
Topics: 72
Posts: 803
|
here is Kaplan's explanation.
Bartter syndrome - JG hyperfunction (AR)
Renin elevated --> incr in AT and aldosterone secretion.
now
The elevation in AT11 results in endicytosis of AT11 receptors  and hence decreases in AT11 activity on blood vessels.
Hypercalciuric metabolic alkalosis is observed.
Mutations can affect several different transporters in the renal tubules.
|
| usmle4me
Forum Elite
Topics: 6
Posts: 283
|
As I remember it said blood vessels are hyporesponsive to AT11.
So A should be the answer
|
| me007
Forum Guru
Topics: 72
Posts: 803
|
another q about Bartter
Attached Files:
PHARM-renal012.jpg (270 KB, 30 downloads)
|
| new_n_lost
Politically InCorrect
Topics: 654
Posts: 6,115
|
B. Loop Diuretics Furosemide.
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| me007
Forum Guru
Topics: 72
Posts: 803
|
why?
|
| new_n_lost
Politically InCorrect
Topics: 654
Posts: 6,115
|
Acts on the Thick Ascending loop of Henle they specifically act upon the Sodium Potassium Chloride Co-transporter which gets mutated in the Bartter Syndrome.
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| new_n_lost
Politically InCorrect
Topics: 654
Posts: 6,115
|
Looked it up in Harrison's found it yup u r right abt Angiotensin II levels
" mutations lead to a loss of Na and Cl reabsorption in the loop of Henle.The resultant volume depletion activates the renin-angiotensin system. Distal delivery of NaCl and water are high in the presence of high aldosterone, promoting secretion of K and H ions. Prostaglandin overproduction is mediated by volume depletion, hypokalemia, and high angiotensin II and kallikrein levels. Increased prostaglandin production contributes to the severity of disease by inducing resistance to the pressor effects of angiotensin II and reducing reabsorption in the thick ascending limb of the loop of Henle."
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| jole
Forum Elite
Topics: 12
Posts: 279
|
nice explanation.Thanks.
___________________
Never underestimate the power of prayer.
|
|
| |
| | | | | | | | | | | | |
