chemamr
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... Aplastic anemia ...
1- what are the diagnostic criteria for aplastic anemia?
2- what is the treatment of choice? for patients >40 years? for <40 years?
3- what are the most common causes ?
4- common side effects of the drugs used for tx of this dz?
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| vrach
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1. Dx of Aplastic Anemia: Pancytopenia + Hypocellular (< 25% hematopoetic cells) fatty bone marrow biopsy.
2. Tx of choice: <40 y/o is bone marrow transplantation; >40 yrs or lacks suitable donor - Immunosuppression with a combination of antilymphocyte globulin (ALG)/antithymocyte globulin (ATG) & Cyclosporine.
4. Common side effects: ALG/ATG - Serum sickness, anaphylaxis (rare); Cyclosporine - nephrotoxicity, hypertension, seizures, oppertunistic infections (esp. Pneumocystis carinii - prophylax with pentamidine); Combination Tx - Myelodysplasia, Leukemia
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| chemamr
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good
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Any time something is written against me, I not only share the sentiment but feel I could do the job far better myself.
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| chemamr
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Topics: 703
Posts: 4,461
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and the most common causes are:
idiopathic in 40-70% of pts.
then: drugs such as chloramphenicol, benzene, phenylbutazone, sulfonamides, gold;
paroxysmal nocturnal hemoglobinuria
and infections.
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Any time something is written against me, I not only share the sentiment but feel I could do the job far better myself.
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