doc_clotaire wrote:
A ) Hyperlipidemia .............. Hypothroidism is related to increased LDL
d ) Unexplained hyponatremia .... Hypothyroidism is related to SIADH
f ) Elevated serum muscle enzymes ( don ' t know why )
Correct and as dr.wad said: elevated serum muscle enzymes due to myopathy.
My question here is WHY does hypothyroidism cause increased release of ADH???
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| vrach
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There is no definitive conclusive evidence as to the cause of hyponatremia in patients with hypothyroidism. All the various explinations given in different sources are just hypothesis. I still haven't come accross one that says excessive ADH is the cause. Could you please give the source of this info?
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| DrVirgo
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The source is USMLE WORLD.
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| vrach
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Ok...I think I found some explination...hypothyroidism causes a decreased CO and GFR, which causes an increased secretion of ADH in response to the hemodynamic changes. But this is not SIADH, infact it is imortant to rule out hypothyroidism as the cause of hyponatremia before you Dx SIADH as the cause. Also decreased renal tubular resorbtion of Na due to deminished Na-K ATPase activity in hypothyroidism also plays a role in the development of hyponatremia.
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