DrVirgo
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From UW:
What is the most prevalent antibody in Hashimoto Thyroiditis?
A. Anti-Thyroid peroxidase antibodies
B. Anti-Smooth Muscle antibodies
C. TSH Receptor blocking antibodies
D. Thyroid stimulating antibodies
E. Anti mitochondrial antibodies
--Also what are the other antibodies found in?
--In which disease are anti-microsomal antibodies found?
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| robin082006
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Here my notes:
List of some autoantibodies and commonly associated diseases
vs. double-stranded-DNA = Systemic lupus erythematosus
vs. Ro or La = Systemic lupus erythematosus and neonatal heart block, primary Sjogren's syndrome
vs. Sm = Systemic lupus erythematosus
vs. phospholipid = Antiphospholipid syndrome
vs. SSA or SSB = Sjogren's syndrome
vs. neutrophil cytoplasmic (cANCA) = Wegener's granulomatosis
vs. neutrophil perinuclear (pANCA) = Systemic vasculitides (non-specific)
vs. IgG (Rheumatoid Factor) = Rheumatoid arthritis
vs. neutrophil perinuclear (pANCA) = Polyarteritis nodosa
vs. centromere = CREST syndrome
vs. Scl70 = Systemic sclerosis
vs. smooth muscle = chronic autoimmune hepatitis
vs. mitochondria = primary biliary cirrhosis
vs. nicotinic acetylcholine receptor = myasthenia gravis
vs. voltage-gated calcium channel = Lambert-Eaton syndrome
vs. thyroid peroxidase (microsmal) = Hashimoto's thyroiditis
vs. TSH receptor = Graves' disease
vs. Hu = Paraneoplastic cerebellar syndrome
vs. voltage-gaed potassium channel (VGKC) = Limbic encephalitis
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| robin082006
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Answer A
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| fox
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So microsomal & thyroid peroxidase are synonymous?
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| chemamr
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fox: I think they are. But the current name is peroxidase (microsomal isn't longer used)
answer is A + antithyroglobulin ab.
I don't know the answer to the last question.
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| chemamr
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antiperoxidase abs are also present in Sjogren, SLE, RA, pernicious anemia and other thyroid disorders (but in less %).
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| robin082006
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Antithyroid peroxidase antibodies (previously known as thyroid microsome autoantibodies) are present at:
* high titre, in:
o Hashimoto's thyroiditis
o idiopathic thyroid atrophy
* low titre, in:
o Grave's disease
o De Quervain's thyroiditis
o 8% of males, and 10% of females without thyroid disease
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| DrVirgo
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OK, so they are synonymous. Thats what I wanted to know because I was used to reading anti-microsomal antibodies for Hashimotos.
Also please note:
they sometimes say Anti Thyroid Peroxidase Antibodies as Anti TPO Antibodies.
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