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epica

02/06/07 - 06:28 PM             #1

Q

Ca channel blocker inhibit Ca influx into
1. Muscle of Artria
2.M. Ventricule
3.AV node
4.Bundle of His
5.Smoth m of Coronary artery


Sayulita
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02/06/07 - 06:35 PM             #2

Muscle Ventricle 2

Clozapine
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02/06/07 - 06:56 PM             #3

I feel so dumb ... I dont really understand the question confused .... I thought CCBs inhibit Ca influx everywhere we have L type Ca channels ... including AV node ( they r anti-arrythmic rite? in AV nodal arrythmia ??? )

can anyone pls explain ... rolling eyes


Ancylostoma
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02/06/07 - 06:57 PM             #4

what happened to my post ?


Ancylostoma
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02/06/07 - 06:58 PM             #5

here it is again....had to press back a million times

I smell poo poo....They block ca channs in cardiac muscle , vascular muscle and thats why they are used in angina/ HTN, they block sa and av nodal CA as well as pacemaker potential and thats why they are used as antiarrythmics.



epica

02/06/07 - 07:02 PM             #6

Ancylostoma, please what do you think?

Clozapine
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02/06/07 - 07:02 PM             #7

that was my point anky, so, it should be 1,2,3,4,5 rite? why pick out one or just #2 confused

Ancylostoma
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02/06/07 - 07:03 PM             #8

I guess if i'm forced to pick, I would pick all. Lol i'm with you, I actually posted the dookie statement earlier. I guess you smelled the dookie too...

epica

02/06/07 - 07:04 PM             #9

I don't have ans.
So, the ans will be AV node?

Clozapine
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02/06/07 - 07:05 PM             #10

I`m not as dumb as i think i am raised eyebrow

me007
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02/06/07 - 07:05 PM             #11

few min ago i was sure that cardiomyocytes in ventricles and atrias are the same ones.


epica

02/06/07 - 07:06 PM             #12

Guys, if you understand this is not my Q

Ancylostoma
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02/06/07 - 07:07 PM             #13

no your not dumb The answer is all of the above .

epica

02/06/07 - 07:19 PM             #14

Ok, sorry.
This is the Q, just copied
Ca channel blockers are antyarrythmic because they inhibit Ca influx into?


Ancylostoma
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02/06/07 - 07:23 PM             #15

phase 0 of pacemaker cells is ca influx, look at pacemaker action potentials, also the decrease the slope of phase 4 which is cardiac pacemaker potential, which is thought to be do to increase in ca influx or na influx or decrease in K efflux or all. They are not sure exacly and thus kaplan says that exact ion that causes pacemaker potential isnt important.

Clozapine
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02/06/07 - 07:25 PM             #16

AVN. by decreasing conduction velocity ... at least thats the reason they r used in arrythmia as far as I remem



me007
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02/06/07 - 07:26 PM             #17

L-type Ca channels - dominant type in cardiac and smooth muscle.
Therapeutic blockers are exclusively L-type channel blockers

epica

02/06/07 - 07:29 PM             #18

Agree, AVN
Thanks

epica

02/06/07 - 07:38 PM             #19

Just found in FA page 257,2007

Mechanism
Primarily affect AV nodal cells. Used in prevention of nodal arrhythmias (svt)







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