sam_step1
Forum Junior
Topics: 23
Posts: 38
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Hi All,
Can any one help me in this Q-
what type of amyloid get deposited in kidney?
Serum AAA/ Primary AL/ Transthyretin/ Beta amyloid?
~Sam.
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| new_n_lost
Forum Hero
Topics: 663
Posts: 6,107
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Apolipoprotein AI amyloidosis (AapoAI) is an autosomal dominant amyloidosis caused by point mutations in the apoAI gene. Usually, this amyloidosis is a prominent renal amyloid. Some kindreds have peripheral neuropathy or cardiac disease. ApoAI (likely of normal sequence) also is the fibril precursor in localized amyloid plaques in the aortae of elderly people.
Here is the link to this quote : http://www.emedicine.com/med/topic3377.htm
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| Ancylostoma
Forum Guru
Topics: 42
Posts: 637
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if its dialysis associated its B2 microglobulin a2b2 or something like that
alziemers = b amyloid
serum AA = inflamatory conditions
Primary al = ? Maybe multiple myeloma, b cells
they are all listed in the kaplan Amyloidosis chapter, there are more
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| sam_step1
Forum Junior
Topics: 23
Posts: 38
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Hi New_n_lost & Ancyclostoma,
Thanks for reply.
New_n_lost - weblink provided by you helped a lot. I appreciate it.
Ancyclostoma- kaplan notes has many amyloid types but do not say any specific for kidney.
Thanks.
~Sam.
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| mildus
Forum Guru
Topics: 19
Posts: 614
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it depends on type of condition: multiple myeloma will be accompagnied by AL deposits in kidneys while chronic inflamations will lead to AA deposition
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