DrVirgo
Forum Hero
Topics: 1096
Posts: 3,515
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A 40-year-old man comes to the clinic complaining of
fatigue. He also reports mild left upper abdominal and
back pain, early satiety, and an unintentional 15-lb
weight loss over the past few months. Before this, he has
been healthy, never having spent a day in the hospital.
His family history is unremarkable; the patient has a
twin brother and an older sister, both of whom are
healthy. Physical examination is remarkable for
splenomegaly and mild tenderness over the lower sternum.
A complete blood count shows:
Leukocytes 85,000/mm3
Hematocrit 31%
Platelets 650,000/mm3
A bone marrow biopsy reveals granulocytic hyperplasia.
Genetic analysis reveals a translocation between chromosomes
9 and 22.Which of the following is the most
appropriate treatment for this patient’s condition?
(A) Cytarabine/busulfan
(B) Hydroxyurea
(C) Interferon-alpha
(D) Interferon-beta
(E) Stem cell transplant
(Clue: diagnosis is CML, whats the treatment?)
___________________
Our greatest glory is not in never falling, but in rising every time we fall.
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| nadiabarati
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E for sure!
a young patient with CML we go for SCT if a good donor is available because some of CML go into AML
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| DrVirgo
Forum Hero
Topics: 1096
Posts: 3,515
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The correct answer is E. This patient has chronic myelogenous
leukemia, definitively diagnosed by the presence
of the Philadelphia chromosome, t(9;22). Medical
treatment options are varied, and the exact protocols
are complex and evolving. However, young patients
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Our greatest glory is not in never falling, but in rising every time we fall.
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| elitoki
Forum Guru
Topics: 54
Posts: 508
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When do we use Gleevac (Imatinib)( thyrosine kinase inhibitor)??
What should I have to choose if there were "stem cell transplant" and "imatinib" together?
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| gordon
Forum Newbie
Topics: 5
Posts: 27
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Basically, all CML patients will try Gleevac (Imatinib) first. If Imatinib is insensitive, then consider SCT.
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