Ancylostoma
Forum Guru
Topics: 42
Posts: 642
|
Joking about the title, but it did get your attention!! ADMIT it !!
Heres a Question, have fun with it!! Give it a guess if you dont know and explain your reasoning.
If you open up the post, you have to at least try the Q out!!
A previously healthy chinese 73 year old man is brought to the emergency department with muscular weakness. He was unable to walk the last 8 hours. His history reveals that within the last two years he has comsumed a large quantity of chinese licorice root as a digestice "Tonic". If excess licorice intake is his condition, which of the following sets of data would be expected in this patient.
Plasma NA, plasma K, Plasma Renin, Plasm ALDOSTERONE, Blood Pressure.
inc=increase dec=decrease
A inc, dec, dec, dec, incr
B inc, dec, inc, inc, inc
C inc, dec, normal, normal, dec
d dec, inc, dec, dec, inc
e dec, dec, dec, dec, inc
Edited by Ancylostoma on 02/02/07 - 10:15 AM
|
| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,058
|
Yup thats true i wouldnt have opened the post unless ur name wasnt Attached it made more curious than usual. Licorice i dont know much abt it had to search it. this is wht i found
http://www.siu.edu/~ebl/leaflets/glycyrrhizin.htm , http://www.umm.edu/altmed/ConsHerbs/Licoricech.ht...
after looking at that my answer is B
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| unique1
InGodITrust
Topics: 19
Posts: 1,410
|
nnl , thanks for the links . I knew about licorice only after reading here.
My answer is also b.
___________________
I can't change the direction of the wind, but I can adjust my sails to always reach my destination.
|
| mytime
Kick my butt!
Topics: 39
Posts: 3,174
|
I wud have thot it was d....but well!
ANCY u brat...I almost spanked u!
|
| Ancylostoma
Forum Guru
Topics: 42
Posts: 642
|
lol I not sure spanking me is a bad thing...I might actually like it(as long as your not a guy). It looks like you peoples gave up the search a little prematurely, I'm surprised that only you three answered out of the people who looked at it. Find the mechanism and you will find the answer!!
If not after a couple of tries i will enlighten yall. I missed it too but I guess it might just be important!!
|
| Ancylostoma
Forum Guru
Topics: 42
Posts: 642
|
Need more people involved!!! Come on!!
|
| unique1
InGodITrust
Topics: 19
Posts: 1,410
|
OK let me try again ...
As it acts on the same receptors as aldosteron and mimics the aldosteron action so Na should go up and K should come down . In licorice overdose aldosteron levels remain normal or low and BP rises .
So should the answer be A 
___________________
I can't change the direction of the wind, but I can adjust my sails to always reach my destination.
|
| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,058
|
High doses of licorice (more than 20 g/day) may cause serious side effects. Too much glycyrrhizin causes a condition called pseudoaldosteronism, which can cause an individual to become overly sensitive to a hormone in the adrenal cortex. This condition can lead to headaches, fatigue, high blood pressure, and even heart attacks. It may also cause water retention, which can lead to leg swelling and other problems. An overdose of glycyrrhizin can lead to harmful conditions such as high blood pressure and even heart attack.
High levels of both renin and aldosterone are normally present when the body is trying to conserve fluid and salt (sodium). When a tumor is present, an aldosterone level will be high while a renin level will be low. Usually a renin activity test is done when the aldosterone level is measured.
these were the 2 reasons i choose B now if there were a choice where Serum Renin was normal or dec then i would have choose something else but after a very close look i wud for Choice A n the answer is locked
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| new_n_lost
Politically InCorrect
Topics: 650
Posts: 6,058
|
Ok found it Ancy really missed it
Glycyrrhizin inhibits the conversion of cortisol to cortisone by inhibiting the enzyme 11-Betahydroxysteroid Dehydrogenase. As a result, cortisol builds up at the collecting duct. Cortisol has intrinsic mineralocorticoid properties (that is, it acts like aldosterone and increases sodium reabsorption) that work on ENaC channels in the collecting duct. Hypertension develops due to this mechanism of sodium retention. People often have high blood pressure with a low renin and low aldosterone blood level.
the link is http://www.answers.com/topic/glycyrrhizin
___________________
FORUM RULES-- Those who believe in telekinesis, raise my hand. I get enough exercise just by pushing my luck --P4U World.." The pure and simple truth is rarely pure and never simple."
|
| unique1
InGodITrust
Topics: 19
Posts: 1,410
|
Ancylo, how is it ??
So it is A han ?
___________________
I can't change the direction of the wind, but I can adjust my sails to always reach my destination.
|
| Ancylostoma
Forum Guru
Topics: 42
Posts: 642
|
Very good glycyrrhizin is the active component of liqorice. Summary: What happens normally is that cotisol will have the abiltiy to stimulate aldosterone receptors in the cortical collecting duct. This is prevented by the presence of 11 b oh steroid dh, and that why it doesnt normally happen. glycyrrhizin inhibits the enzyme and causes A low renin htn, with high levels of NA and low K+. Looks like you found a good place to look up the info. It also looks like we all learned something new.
If you guys get a funky question, post it. It would be a good learning experience for us all.
|
| mytime
Kick my butt!
Topics: 39
Posts: 3,174
|
dart i almost had it....but i tried without researching..so 
|
| me007
Forum Guru
Topics: 72
Posts: 803
|
understanding licorice
symptoms of hyperaldosteronism (or exess mineralocorticoids) with low aldosterone,
bcs it lets cortisol do aldosterone's job.
tricky
|
| keepgoing
Forum Guru
Topics: 62
Posts: 1,673
|
thanks really good....and ur title a real eye/mind catcher....thot whyyyy dumb???? u got tricks man...
after reading at link yes agree with nnl n others ans a.
|
| Ancylostoma
Forum Guru
Topics: 42
Posts: 642
|
well hope everyone found this one interesting, I'm entering the final month of my prep and will probably not post so much anymore...Good luck on the test
|
| Fertile
Forum Newbie
Topics: 0
Posts: 3
|
Not boastiin, but This question is a piece of cake for those who hav read Ganong, 21st edition
pg # 379 heading : relation btw mineralocorticoid to gluocorticoid receptors, + the heading underneath is worth a READ
|
| FATIN
Forum Newbie
Topics: 1
Posts: 8
|
what's Ganong, 21st edition ?
|
|
| |
| | | | | | | | | | | | | | | | | |
