keepgoing
Forum Guru
Topics: 62
Posts: 1,673
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- The results of linkage analysis for marker A and the NF-1 gene are shown below. What is the approximate genetic distance between marker A and the NF-1 gene?
 - 0.1cM
- 0.5cM
- 1cM
- 10cM
- 30cM
plz explain as well!
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| babydoc4usmle
Forum Guru
Topics: 18
Posts: 634
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it's 10cM
LOD>3 means linkage
1% of recombination event = 1cM distance between genes
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| D_N
Forum Junior
Topics: 16
Posts: 37
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how does this gives 10cM???
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| SmokyWaters
Forum Elite
Topics: 6
Posts: 458
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look at the LOD scores...
the maximum LOD score is with recombination frequency of 0.1 ...
this means that this is the RECOMBINATION frequency associated with the linked gene...
0.1 recombination frequency means 10% recombination frequency...
1% recombination frequency = 1 cM = 1Mbp distance on chromosomes
10% means 10cM 
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| sureshrx
Forum Newbie
Topics: 5
Posts: 33
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wher d u find the question and better still where d u find the answer? and pl what does LOD mean? me just sarting off . so pl help
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| sureshrx
Forum Newbie
Topics: 5
Posts: 33
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starting off... sorry
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| neopulsar
Forum Senior
Topics: 13
Posts: 82
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sureshrx; you can find it in Kaplan lecture note (biochem/genetics p. 371, 2006-7 edition)
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| sureshrx
Forum Newbie
Topics: 5
Posts: 33
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thanks a lot . thought was missing out something
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