Sayulita
Forum Guru
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Posts: 548
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Patient with MI is given tissue plasminogen activator
wich is the most common complication and why ?
a.-anaphylatic reaction
b.-atrial tachyarrhythmia
c.-hemorrhage
d.-hypotension
e.-thrombosis
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| me007
Forum Guru
Topics: 72
Posts: 799
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c.
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| Sayulita
Forum Guru
Topics: 105
Posts: 548
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good I see that you are really studying
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| Sayulita
Forum Guru
Topics: 105
Posts: 548
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The agent is known as a "clot buster",bacause of its mechanism of action:it binds to fibrin in a thrombus and converts the entrapped plasminogen to plasmin,wich initiates fibrinolysis and essentially dissolves the thrombus
Since tPA is a thrombolytic,bleeding {hemorrhage} is the most common complication
or side effect
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| mildus
Forum Guru
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that's right, but could allergic reaction also happen?
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| arlete
Half way there!
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Allergic reaction could happen with any drug. But regarding thrombolitics, think risk for allergy = streptokinase (when the patient has antibodies against Streptococcus). With tPA, the risk for hemorrhage is much greater. 
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Que sera sera, whatever will be will be.
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| mildus
Forum Guru
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thanks arlete, I agree with you;
I read somewhere that streptokinase wiould have no effect if patient received streptokinase in previous two years
Edited by mildus on 02/26/07 - 12:28 PM
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