kiranmayi
Forum Guru
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A 14-year-old female presents to her family practice physician for a school physical. Her only complaint is pain in her left calf and ankle. She has no significant medical history. Family history is significant for a father who died at age 30 of a myocardial infarction and a paternal uncle who died at age 36 of a myocardial infarction. Her paternal grandmother died in her 40 s of an unknown cause. The physical exam reveals soft, yellowish elevated plaques on both of her eyelids. The patient also has a tender nodular elevation about 1.5 cm in diameter in the area of the left Achilles tendon. Her lab results are significant for an elevated low-density lipoprotein (LDL) of 821. Which of the following is the most likely etiology of this patient's elevated LDL?
A. A defect in bile acid synthesis
B. A defect in HMG-CoA reductase enzyme production
C. A defect in the LDL receptor
D. A defect in the storage of cholesterol esters
E. A diet high in fat
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| asmi
Forum Hero
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Posts: 4,609
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C...defect in LDL receptor..since its type IIA hypercholestrolemia
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| kiranmayi
Forum Guru
Topics: 237
Posts: 407
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true
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