lq2006
Forum Elite
Topics: 43
Posts: 382
|
If renal tubular CAs were totally inhibited, you would except increase excretion of which followings? (select all correct answer)
A.sodium
B.water
C. bicarbonate
D. potassium
Please explain your answer.
|
| Clozapine
Forum Elite
Topics: 15
Posts: 167
|
I would expect an increase in excretion of
B.water
C. bicarbonate
D. potassium
Bicarbonate b/c CA inhibitors prevent formation of carbonic acids in tubular lumen and thereby cause bicarbonaturia
decreased diffusion of carbonic acid in the tubular cells plus inhibition of CA inside the cell would again prevent breakdown of carbonic acid inside cell and there would be decreased Hydrogen ions available for Na+/H+ antiporter --> decreased Na+ uptake by cell ---> increased Na+ load downstream with retained water
Na+ exchanged for K+ in CT causes increased potassium excretion
|
| Ancylostoma
Forum Guru
Topics: 42
Posts: 642
|
Na too. everything clozapine mentioned plus NA. While there is increase load for Na in the DCT and CD, not all of it can be exchanged for K and H+. So you will have elevated leves of NA, K, HCO3, and water in the urine.
|
|
| |
| | | |
