Ancylostoma
Forum Guru
Topics: 42
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You and your sneaky biochem questions I might be overthinking this question but I think the absence PEPCk might be the answer.
C The absence of pep ck would impair gluconeogenesis, and it might cause pyrucate to build up, preventing the conversion of lactate (coris cycle) back into pyruvate and then to Glucose. This may lead to a large rise in lactate levels. Thats my thinking, though I'm not sure.
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| Ancylostoma
Forum Guru
Topics: 42
Posts: 642
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I wrote that before I saw your smiley, so I guess that means I'm right ?
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| Ancylostoma
Forum Guru
Topics: 42
Posts: 642
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where are you getting these questions ? Kaplan, usmle rx , etc?
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| me007
Forum Guru
Topics: 72
Posts: 803
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it is C!
same enzyme as in q-3. 
Goljan's biochem book.
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| Luckyall
Forum Guru
Topics: 11
Posts: 592
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Oh my God, thas an excellent Qs !!! You and your sneaky biochim Qs
I have a Qs .... wich Goljan biochim book ? Rapid Review Series biochim you mean ? If yes, what edition, 1 st or 2 nd ?
Than other Qs : i have the CD of the 1 st edition of Rapid Review biochim, are there any additional Qs in the book itself other then on the CD ?
I will take a look on these Qs no matter what... great sneaky Qs
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| me007
Forum Guru
Topics: 72
Posts: 803
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2nd edition.
can't compare with 1st one or cd, sorry
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| Luckyall
Forum Guru
Topics: 11
Posts: 592
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Thanks , is all worth it !
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| angelsourire
Forum Newbie
Topics: 1
Posts: 4
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I think that the answer is a.
The reason why is that why in fasting stages, the liver is going to get into gluconeogenesis in the liver to level the glucose level for energy, the substrate used is lactate.
The von Gierke disease is characterizes by low serum glucose and high serum lactate resulting from deficiency of glucose-6-phosphatase
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| thornflier
Forum Newbie
Topics: 4
Posts: 15
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agree with answer C. Glucose-6-phosphatase deficiency can also cause this situation, but the G6PD in answer a means G6P dehydrogenase. Just need to be careful.
GL.
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| dioben
Forum Newbie
Topics: 2
Posts: 8
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can somebody tell me why not Pyruvate Kinase
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| lq2006
Forum Elite
Topics: 43
Posts: 382
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PEP carboxikinase
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| Addicudo
Forum Guru
Topics: 124
Posts: 608
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 PEPCK .. it is .. !! Its not Pyruvate Kinase .. as the Question says that there is an increase in Lactate .... During Gluconeogenesis ... Lactate is needed (Just like Alaninie) and PEPCK form OAA and then the Malate shuttle stuff .. !! So if PEPCK is absent Lactate wil accumulate ... If it were Pyruvate kInase def .. then there would be no Pyruvate formed in teh first place ... and that disease has a seperate set of Symptoms .. mainly Anemia .. !! so hope it clears a bit .. !!
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