Palaniappan
Forum Senior
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Posts: 148
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Hey..Please calrify me in this aspect..
What happens to Cl- and Na+ channel exactly in the ducts...I am confused since USMLE World says that there are two different mechanisms of the normal CFTR protein in sweat ducts and pancreatic ducts...
In sweat ducts : Normally,Cftr-->Cl- secretion and Na+ reabsorption
In pancreatic ducts--->What happens??
Just clarify the secretion and reabsorption fact of Na and cl in Cystic fibrosis
Thanx
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| new_n_lost
Forum Hero
Topics: 724
Posts: 6,397
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Hope this helps u
Defective CFTR results in decreased secretion of chloride and increased reabsorption of sodium and water across epithelial cells. Mutations in the gene for CFTR (CFTR) result in abnormalities of cAMP-regulated chloride transport across epithelial cells on mucosal surfaces.decreased hydration of mucus results in mucus that is stickier to bacteria, which results in infection and inflammation. These abnormalities result in viscid secretions in the respiratory tract, pancreas, gastrointestinal tract, sweat glands, and other exocrine tissues. Increased viscosity of these secretions makes them difficult to clear
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| Palaniappan
Forum Senior
Topics: 30
Posts: 148
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thanx new..
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| Ancylostoma
Forum Guru
Topics: 42
Posts: 636
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the chloride secretion keeps Na in the lumen from being reabsorbed. When the chloride is not secreted like in cystic fibrosis, Na is reabsorbed and water follow. What is left is thick viscous secretion causing the problem. Make sure you know this as I had a questions which the answer was increased Na reabsorbtion(usmle world)
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| Palaniappan
Forum Senior
Topics: 30
Posts: 148
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You are right anky...That's what confused me:-)..
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