Palaniappan
Forum Senior
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A patient with increased serum creatinine needs a drug to be administered which is cleared non-renal and preferentially by hepatic clearance.The drug should have which of the following property..
A.Poor penetration into CNS
B.Low Vd
C.Increased lipophilicity
D.Low redistribution
E.Poor oral absorption
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| drplacebo
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B....!!
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| Clozapine
Forum Elite
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Is it C ? (b/c lipid soluble drugs are not cleared by kidney?)
My guess is C
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| Palaniappan
Forum Senior
Topics: 30
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Yes..It is C.Lipid soluble drugs are better excreted through liver in bil;e and feces.
What is the difference betweeen volume of distribution and redistribution???Both can increse the blood levels...can anyone add on to that???
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| Ancylostoma
Forum Guru
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I think I would fully agree with you and clozapine
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| Clozapine
Forum Elite
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Redistribution is one of the ways drug actions are terminated in body ( other primary ways are metabolism/excretion) ... usually seen in case of highly lipid soluble drugs, when infused/injected--> plasma level rises --> diffuses to site of action ---> infusion stopped/plasma level drops ---> since highly dissusible, comes out of site of action and redistributes in other tissues). I dont think redistribution increases the blood level though !!
Importance of redistribution is, I guess, drugs with this property have rapid onset of action as well as rapid termination of action ... like thiopental
Vd shows the relationship b/w amount of drug in body and plasma conc. of the drug ( i guess, it doesn`t matter if the drug is highly tissue protein bound or redistributed, what we are measuring here is how much drug is in plasma in comparison with extravascular tissue)
and Vd is inversely related to blood level  lower the plasma conc. higher the Vd
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| Palaniappan
Forum Senior
Topics: 30
Posts: 148
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Thanx Clozapine...
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