Ancylostoma
Forum Guru
Topics: 42
Posts: 642
|
1) very small amounts are require to saturate the enzyme. After its saturated it can only break down a consistent amount rather then proportion.
2) Facilitates gaba, there are more I cant remember
3) Dont know this one ? aldehyde dh ( breaks down the aldehydes created by alcohol dh but I think your looking for another answer
Edited by Ancylostoma on 01/13/07 - 12:24 PM
|
| Clozapine
Forum Elite
Topics: 15
Posts: 167
|
Hi Ancylostoma,
Thanks for the response.... I got these facts while going thru Katzung review... You are absolutley right about the 2nd and about the 1st one too (technically) ...anyways, here are the exact answers~
Ans.1. Due to limited supply of NAD+ required in ethanol metabolism ---> fixed
capacity of ethanol metabolism = 7-10 gm/h
Ans.2. Facilitates action of GABA @ GABA(A) receptor
Inhibits binding of Glutamate to NMDA receptor
Ans.3. MEOS (Microsomal Ethanol Oxidizing System) @ >100 mg/dL of blood level
of Ethanol
|
| Ancylostoma
Forum Guru
Topics: 42
Posts: 642
|
is there anyway you can provide more information about the microsomal ethanol oxidizing system?
|
| Clozapine
Forum Elite
Topics: 15
Posts: 167
|
|
| Clozapine
Forum Elite
Topics: 15
Posts: 167
|
Clozapine wrote:
|
| Clozapine
Forum Elite
Topics: 15
Posts: 167
|
Microsomal Ethanol Oxidizing System (MEOS)
This enzyme system, also known as the mixed function oxidase system uses NADPH as a cofactor in the metabolism of ethanol.
At blood concentrations below 100 mg/dL (22 mmol/L), the MEOS system, which has a relatively high Km for alcohol, contributes little to the metabolism of ethanol.
However, when large amounts of ethanol are consumed, the alcohol
dehydrogenase system becomes saturated owing to depletion of the
required cofactor, NAD+. As the concentration of ethanol
increases above 100 mg/dL, there is increased contribution from the
MEOS system, which does not rely upon NAD+ as a cofactor.
During
chronic alcohol consumption, MEOS activity increases. As a result,
chronic alcohol consumption results in significant increases not only
in ethanol metabolism but also in the clearance of other drugs eliminated by the MEOS system. Similarly, other inducing drugs such as barbiturates
may also enhance the rate of blood alcohol clearance slightly. However,
the effect of other enzyme-inducing drugs on ethanol clearance is less
important because the MEOS is not the primary pathway for ethanol
metabolism.
|
| Clozapine
Forum Elite
Topics: 15
Posts: 167
|
I tried to add the figure too  ... can't paste it
|
| Clozapine
Forum Elite
Topics: 15
Posts: 167
|
Awesome :P
Made it !!!
|
| Ancylostoma
Forum Guru
Topics: 42
Posts: 642
|
Interesting. Thanks for the Post and the time. You have now given me a greater understanding on ethanol metabolism. I bow down ... :-)
|
| Clozapine
Forum Elite
Topics: 15
Posts: 167
|
:P
And guess what .... GI metablosim of alcohol is much lower in female than in male ... so, now we know why they say ... "Can I buy u a drink?" :P
|
|
| |
| | | | | | | | | | |
