Palaniappan
Forum Senior
Topics: 30
Posts: 148
|
hI,
From this wierd transplant rejection,can anyone explain whether this concept is ok?
GVHD (Graft versus host disease) : Donor T cells are sensitised against the MHC antigens in the host cells
HVGD(Host versus Graft disease) : Recipient T cells are sensitised against MHC antigens of the donor cells.
Thanx
|
| babydoc4usmle
Forum Guru
Topics: 18
Posts: 634
|
no, GVHD= donor's T cells reject recipient's ALL cells as "non-self" and destroy practically everything IN THE HOST (RECIPIENT)
HVGD=recipient's immune system sees dono'r organ/cells as "non-self" and destroyes TRANSPLANED tissue
|
| Palaniappan
Forum Senior
Topics: 30
Posts: 148
|
Thanks babydoc...So..Bone marrow transplant without irradiation is an example of GVHD and most other transplant rejections are HVGD...Right??
Can you drop in some more examples of these reactions??
|
| babydoc4usmle
Forum Guru
Topics: 18
Posts: 634
|
before bone marrow transplant Pt receives irradiation so HOST would not react to transplanted tissue, but DONOR's BM is not inactivated and that is why GVHD MIGHT HAPPEN, but not necessay WILL happen.
as for GVHD i don't know any other situation other than BMT (transplanted cells ARE CELLS OF IMMUNE SYSTEM tha are capable to launch immune respond)
HVGD - any ALLOGRAFT (liver, kidney, lung...you name it) can cause this reaction
|
| Palaniappan
Forum Senior
Topics: 30
Posts: 148
|
Thanx again babydoc..Just now checked it out...GVHD can occur in any organ with increased lymphocyte count..Examples-Blood cells without irradiation,Even liver cells.
|
| Clozapine
Forum Elite
Topics: 15
Posts: 164
|
yepp....and theoretially also in case of thymus and spleen implant in immunocompromised patient ... anything with lymphocytes !!
|
|
| |
| | | | | | |
