sam_step1
Forum Junior
Topics: 23
Posts: 38
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Hi All,
Can any one tell me -
Q. What type of of hypersensitivity reaction (hs Rxn) is used for Subacute & Chronic type of Graft verses Host reaction (GVH Rxn)?
For Acute type of GVH Rxn we know being preformed antibody used; it is type II hs Rxn and for Delayed type og GVH Rxn it's type IV hs rxn. But I am not sure about Subacute & Chronic types.
~Sam.
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| Clozapine
Forum Elite
Topics: 15
Posts: 164
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Graft rejection (aka HVG, note GVHD ~ that`s some other thing) is of 4 types
Hyperacute~ reaction occurs due to preformed Antibody ~ Type II Hypersensitivity
Accelerated~ reaction occurs due to reactivation of sensitized T cells (e.g. a second allograft from the same donor is applied to a sensitized recipient, rejection occurs in 5-6 days, since T cells are presensitized) ~ Type IV
Acute~ reaction occurs due to primary activation of T cells (main cause), but antibodies might also play roles. I`m not sure if it`s a type IV, coz antibodies play role, and also T cells are not presensitized (someone please correct me)
Chronic ~ reaction requires months to occur and the pathology involved is unclear...antibodies/immune complexes/slow cellular reaction etc. ~ so , not sure either....
Anyways, precisely,
Hyperacute HVGD = Type II
Accelerated HVGD = Type IV
GVHD = Type IV
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| MRMAVERICK
Forum Guru
Topics: 43
Posts: 775
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good going clozapine
___________________
245/264/CS awaiting result/2006 Grad/Need VISA
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| Clozapine
Forum Elite
Topics: 15
Posts: 164
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Thanks MRMAVERICK  ... please do correct me whenever you see I`m wrong (ofcourse if you get time)..I`d really appreciate that 
May you have all the luck like Bret Maverick (if that was the inspiration behind ur screen name) happy studying
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