MDcooper
Forum Guru
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A 2-year-old girl is brought to the clinic with headache, vomiting, and pallor. Her blood pressure is 130/80 mm Hg. On physical examination, she is noted to have aniridia and a large abdominal mass. Abdominal scanning reveals a poorly vascularized tumor in the upper pole of the right kidney. Which of the following is the most likely cause of this presentation?
A.
Deletion of a gene on
chromosome 11
B.
Fragile X syndrome
C.
Translocation of chromosome 9
and 21
D.
Trisomy 13
E.
Turner syndrome
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| prathapdoctor
Forum Elite
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its WAGR SYN,but i dont know the exact genetic cause,but by exclusion i will go with option A.
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| mazinger
Forum Guru
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agree wt1 is a tumor suppressor gene located in the 11th chromosome....
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original mazinger z
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| robin082006
Forum Hero
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yes this is WAGR syndrome, chromosome 11
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| MDcooper
Forum Guru
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can u name the components of WAGR?
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| robin082006
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Topics: 471
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W: Wilms tum
A: Aniridia
G: Genitourinary anomalies
R: mental Retardation
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