Palaniappan
Forum Senior
Topics: 30
Posts: 148
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Which enzymes are responsible for producing the direct donors of nitrogen into the pathway producing urea?
A.Arginase and Arginosuccinate lyase
B.Glutamate dehydrogenase and glutaminase
C.AST and CPS-1
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| alb123
Forum Newbie
Topics: 1
Posts: 29
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I think it is C. I recall that CPS-1 donates the first Nitrogen group from NH3. The second Nitrogen should come from aspartate being added when citrulline is converted to arginosuccinate by arginosuccinate synthatse. I would assume that an AST is used to do this. Hopefully someone can back me up or prove me wrong.
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| Ancylostoma
Forum Guru
Topics: 42
Posts: 642
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I'm going to agree with alb123. The donors of urea are CP-1 and Aspartate. Ast give glutamates amino group to Oxaloacetate forming aspartate.
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| Palaniappan
Forum Senior
Topics: 30
Posts: 148
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Yes.It is C.:-)
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| Palaniappan
Forum Senior
Topics: 30
Posts: 148
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Hi..I am not sure about this...Which is the immediate donor of notrogen in urea cycle..Is it aspartate or Glutamine?
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| alb123
Forum Newbie
Topics: 1
Posts: 29
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aspartate and NH3 are the two donors of Nitrogen in the urea cycle.
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| Palaniappan
Forum Senior
Topics: 30
Posts: 148
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BUt Nitrogen can also come from the action of glutaminase on glutamine in the intestinal tissues..Is it not a source??Please explain
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