dxtxpx
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The presence of HbF in blood of children and adults is characteristic of
a) alpha thalasemia
b) beta thalasemia
c) megaloblastic anemia
d) sickle cell anemia
e) spherocytic anemia
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| peekay
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it is beta thal
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| dxtxpx
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correct
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| krsma
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what happens in alpha thal.? :?:
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| dxtxpx
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Thalassemia is a hemoglobinopathic anemia in children of Italian and Greek heritage due to partial or complete failure of formation of globin chain in their erythrocytes. In alpha thalassemia there is a gene deletion on chromose 16, and in beta thalassemia there is defect on chromosome 11. Children in whom the trait is homozygous develop a severe anemia (thalassemia major). Those who are heterozygous have mild anemia (thalassemia minor). In beta thalassemia, beta chain formation is defective. HbA production is decreased, and there is increased formation of HbF (fetal Hb) and HbA2, which do not contain beta chains. The Hb in erythrocytes contains an excess of alpha chains, which may be responsible for hemolysis in beta thalassemia
Alpha thalassemia syndromes
Alpha globin genes 4: normal, normal Hct
Alpha globin genes 3: silent carrier, normal Hct
Alpha globin genes 2: Thalassemia minor, Hct 32-40%, MCV 60-75 fL
Alpha globin genes 1: HbH disease, Hct 22-32%, MCV 60-70 fL
Alpha globin genes 0: Hydrops fetalis
Beta thalassemia syndrome
NORMAL Beta Globin genes
Homozygous beta: HbA 97-99%, HbA2 1-3%, HbF <1%
Homozygous beta o: HbA 0%, HbA2 4-10%, HbF 90-96%
Homozygous beta+: HbA 0-10%, HbA2 4-10%, HbF 90-96%
THALASSEMIA INTERMEDIA
Homozygous beta+(mild): HbA 0-30%, HbA2 0-10%, HbF 6-100%
THALASSEMIA MINOR
Heterozygous beta o: HbA 80-95%, HbA2 4-8%, HbF 1-5%
Heterozygous beta+ : HbA 80-95%, HbA2 4-8%, HbF 1-5%
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| Cedrick
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Excellent one out of the grave
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| muzammil
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the answer to the question is definitly beta thalasemia
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| muzammil
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very nice expalnation from dxtxpx got it all revised
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| arbaz
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wat o and + mean
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| MRMAVERICK
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beta thalessemia
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