Luay
Forum Newbie
Topics: 4
Posts: 5
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Hey everyone,
To which side does the oxygen dissociation curve shifts in :
1. Anemia. (generally,no specifications).
2. Sickle Cell Disease.
Please provide more answers if you know of any variations with other types of anemias (for instance, due to acute hemorrhage. ...etc.).
Thank you
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| me007
Forum Guru
Topics: 72
Posts: 803
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HbS has low oxygen affinity - shifts curve to hte right.
anemia iron deficient shoulnd't have any affect on curve (if Hb is normal)
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| Ancylostoma
Forum Guru
Topics: 42
Posts: 642
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to my knowledge anemia of iron deficiecy doesnt shift the curve, but because of decrease oxygen carrying capacit of the blood, the height of the curve decreases. its been a long time since I have done hematology, so I urge you to check
Edited by Ancylostoma on 12/28/06 - 04:13 PM
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| me007
Forum Guru
Topics: 72
Posts: 803
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(HbS has low oxygen affinity - shifts curve to hte right. )
My mistake - Hb S does not shifts curve to the right, HbS is sickling in low O2 tension, it is globin chain defect.
Pyruvate kinase deficiency anemia will shift curve to the right - increase O2 release because there is more 2,3 DPG produced.
Methemoglobinemia will decrease O2 capacity - iron in oxydazed form - height of curve decreased.
Iron deficiency - decreased O2 carring capacity of blood but not O2 carring capacity of Hb. Hb still has 4 Fe 2+. (It is Hb-O2 dissociation curve.)
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| sprint123
Forum Guru
Topics: 129
Posts: 870
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Hi..Can you please explain what is the difference between o2 carrying capacity of the blood and that of the Hb?
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