MDcooper
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5-year-old boy suffers from a condition characterized by recurrent fungal and viral infections, thymic
hypoplasia, tetany, and abnormal facies. Serum levels of immunoglobulins are mildly depressed, and lymph node biopsy shows lymphocyte depletion of T-dependent areas. Which of the following is the underlying pathogenetic mechanism?
A. Developmental defect of the third/fourth pharyngeal pouches
B. In utero infection by human immunodeficiency virus (HIV)
C.Mutations of an autosomal gene encoding adenosine deaminase
D.Mutations of an X-linked gene coding for a cytokine receptor subunit
E. Mutations of an X-linked gene coding for a tyrosine kinase
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| Aashi
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A-------->Developmental defect of the third/fourth pharyngeal pouches
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| prathapdoctor
Forum Elite
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A, its digeorge syndrome.
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| webjeee
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a too. Is there any trick?
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| robin082006
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A, recurrent infections+hypocalcemia--> Digeorge.
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| MDcooper
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correct
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| raghavesh_p
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A, digeorge syndrome
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| chemamr
Moderator and PGY1
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it must be A.
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