DrVirgo
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Can anyone please explain how the secretin stimulation test works for the diagnosis of Zollinger-Ellison Syndrome?
Normally Secretin supresses gastrin.
In ZE, an injection of secretin will INCREASE gastrin. (WHY does this occur?)
Thanks. 
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| DrVirgo
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anyone?
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| MDcooper
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it simply shows that the source of gastrin is not the stomach and it is somewhere else like pancresae in ZE and secretin is unable to suppress it.
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| ssrpk
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exactly, u are basically not taking the picture correctly, its not tht secritin is increasing gastrin in ZES, rather secretion of gastrin is autonomous and not amenable to suppression by secritin!
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