mjl1717
Forum Hero
Topics: 955
Posts: 5,451
|
In north america 70% of cases of CF are caused by what kind of mutation?
a)frameshift
b)misssense
c)silent
d)nonsense
e)translocation
f)RNA splicing
___________________
Smell the coffee! "Is That an Osler move??"
|
| dxtxpx
Forum Guru
Topics: 259
Posts: 1,233
|
choice a) frame shift
|
| phuluong2k
Forum Fanatic
Topics: 714
Posts: 2,008
|
to mjl
I have read a lot of discussion about this topic but no clear answer :lol: , and my own opinion is missense mutation
Do you have the correct answer ?
Thanks
|
| anatomy
Forum Guru
Topics: 101
Posts: 423
|
a)frameshift
i think but not sure?
|
| mjl1717
Forum Hero
Topics: 955
Posts: 5,451
|
No , Im not totally sure, but if you search the archives there is a long thread on this from 15/3 /04
___________________
Smell the coffee! "Is That an Osler move??"
|
| mjl1717
Forum Hero
Topics: 955
Posts: 5,451
|
I believe the concensus was missense.
___________________
Smell the coffee! "Is That an Osler move??"
|
| phuluong2k
Forum Fanatic
Topics: 714
Posts: 2,008
|
i think mjl is right
Mutation spectrum: 50% missense, 20% frameshift, 15% nonsense, 15% splicing, large deletions or other
i pick this on an website
http://www.ich.ucl.ac.uk/cmgs/cfgtp00.htm
|
| phuluong2k
Forum Fanatic
Topics: 714
Posts: 2,008
|
I think we can beat this until its death 8)
In most case of cystic fibrosis 70% it is due to DF508, an in frame mutation.
Beside this, there are a lot of many other mutation, not only DF508, as nonsense, missense, frame shift etc. And among these Missense mutation is the most common.
It is my own opinion
|
| mjl1717
Forum Hero
Topics: 955
Posts: 5,451
|
In pure slang: "I feel you"
Did you see that long thread in the archives from 15/3/04 on C.F.?
Also in black and white Id say Sickle cell disease and or Diabetes mellitus and all their intricacies is worthy of being beaten to death also!
Good looking out! 
___________________
Smell the coffee! "Is That an Osler move??"
|
| Budlight
Forum Senior
Topics: 9
Posts: 92
|
Hi, I think the mutation involving phenylalanine at the DF508 position in Cystic fibrosis is a delition -
i.e. deletion of phenylalanine at the DF508 position of chromosome 7? i think!
and it must be a nonsense mutation because it produces a truncated protein. (im not sure about that)
But inframe and frame shift are usually for duchennes and beckers musculodystrophy!
What dyu guys think?
|
| phuluong2k
Forum Fanatic
Topics: 714
Posts: 2,008
|
In cystic fibrosis there are alot of responsible mutations such as non sense, missense, inframe, frame shift etc each ethnic has a diffrent frequency of genetic mutation
As you say, the most common mutation DF 508. by definition it is a deletion of 3 bases :arrow: it is inframe mutation
Frame-shift is responsible for Duchenne MD :arrow: More severe
In-frame is responsible for Beckers MD :arrow: Less severe
|
| mjl1717
Forum Hero
Topics: 955
Posts: 5,451
|
Important info!
___________________
Smell the coffee! "Is That an Osler move??"
|
|
| |
| | | | | | | | | | | | |
