macTT
Forum Senior
Topics: 32
Posts: 86
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Hey guys,
I never seem to get the correlation between acidosis and decrease in contractility. Can anyone purpose a possible mechanism? Thx
JACK
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| me007
Forum Guru
Topics: 72
Posts: 803
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd...
But if the question is about cardiogenic shock complication it is metabolic acidosis due to tissue hypoxia (lactic acid)
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| macTT
Forum Senior
Topics: 32
Posts: 86
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Me007.
Thx for the find....it was very helpful reading it. I really thank you for the help.
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| Palaniappan
Forum Senior
Topics: 30
Posts: 148
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can this be a possible explanation??
Acidosis--->Hyperkalemia---->Decreased repolarisation--->decrease in contractility?????
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| macTT
Forum Senior
Topics: 32
Posts: 86
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Palaniap,
Shouldn't hyperkalemia cause increase in contractilty since you K+ are not comming out of the cell, which in turn makes the cell more postivie; hence more forceful contraction?
JACK
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| Palaniappan
Forum Senior
Topics: 30
Posts: 148
|
Hi jack,
I thought of this process
Acidosis-->Extracellular hyperkalemia--->Decreased potassium conductance---->Decreased rate of repolarisation--->decreased rate of contraction......though it might be forceful..
I am not sure.
Can someone throw some more light on this???
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