robin082006
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A 25-year-old male presents to his physician with dyspnea and fatigue for the last few weeks. He is a non-smoker and there is no family history of asthma or any blood disorder. He does not take any medications. Examination shows pallor, scleral icterus and splenomegaly.
Lab tests show
Hematocrit 20%
WBC-count 10,000/micro-L
Platelet count 180,000/miro-L
Total Bilirubin 7 mg/dL
Direct bilirubin 0.6 mg/dL
BUN 10mg/dL
Serum creatinine 0.7 mg/dL
Serum LDH 400 U/L(normal value is 80-280 U/L)
Serum haptoglobin 160mg/dL (normal value is 30-220 mg/dL)
Reticulocyte count 8 %
Peripheral blood smear shows spherocytes with central pallor.
Osmotic fragility testing and direct Coomb’s test are positive.
Based on these findings, what is the most likely diagnosis?
A. Hereditary spherocytosis
B. Autoimmune hemolytic anemia
C. Paroxysmal nocturnal hemoglobinuria
D. Sickle cell anemia
E. G6PD deficiency
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| mjl1717
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sounds like H.S.
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| farewel
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A
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| drashishmahajan
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it can nt be HS since in tht coombs test ll be negative.... it is AUTOIMMUNE haemolytic anaemia... other thn H.S spherocytes r found in autoimmune haemolytic anaemia,,G-6PD,,,cirrhosis
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| anjushree
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YES,B
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| robin082006
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ANSWER IS B
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| fox
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what about haptoglobin in aha? how is it affected?
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| prathapdoctor
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haptoglobin could be normal in both heriditary spherocytosis and autoimmune hemolytic anemia.
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