macTT
Forum Senior
Topics: 32
Posts: 86
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Hey guys got stuck on this question...
A 3yr old boy has a mutation in the Ca2+ receptors on the cell surfaces of his parathyroid gland and on the basloateral side (blood) of the ascending loop of henle. Which of the following is expected w/ a mutation that leads to activation of its receptor w/ abscence of its ligand, ca2+ ?
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| alb123
Forum Newbie
Topics: 1
Posts: 29
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Im not really sure, but i think its B.. The mutation in the parathyroid gland would cause increased PTH which would yield higher levels of calcium in the blood. This hypercalcemia cant be reabsorbed in the kidney because of the basolateral surface defect, therefor causing hypocalciuria.
correct me if im wrong..
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| macTT
Forum Senior
Topics: 32
Posts: 86
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Hey bro,
Thx for trying....really appreciate it......However my take on this question is that PTH would be high since it is activated thus leading to a high serum calcium.....and on the other hand since the basolateral side of the blood receptors are activated, it won't absorb much cA2+ so it would yeild hypercalceuria. So I am guessing A not sure....Very tough.
JACK
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| alb123
Forum Newbie
Topics: 1
Posts: 29
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Alright, i looked up some info. on ascending loop of henle and it doesnt mention anything about Calcium secretion or absorption. Is the questions sopposed to ask about the thick ascending limb and not the ascending limb of the loop of henle? But after looking stuff up, I agree with hypercalciuria, if the thick ascending limb is affected because less Ca2+ is reasborbed to the blood.
let me know
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| macTT
Forum Senior
Topics: 32
Posts: 86
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Alb,
I am pretty sure it is the thich ascending limb becuase that is a place that can absorb Mg2+ and Ca2+.
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| NE
Forum Guru
Topics: 53
Posts: 504
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Mutation in Henle- no Ca resorbtion---hypercalciuria+hypocalcemia which SHOULD increases PTH but there is a mutation too so I guess is HYPERCALCIURIA, HYPOCALCEMIA, LOW PTH.
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| brutus25
Forum Junior
Topics: 13
Posts: 62
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Guys if someone would be so kind as to repeat the question , because I could not guess what w/ means ? or w/a ( with / without )
Thank you
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