what to do
Forum Senior
Topics: 29
Posts: 88
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sorry to bother you guys again. but i have no other hope than to keep on poking you. so i am putting some pharma qs as well. and plz plz someone send me some answer
18. A 68-year-old woman has breast cancer that is metastatic to the axillary lymph nodes. The primary tumor is excised and chemotherapy, including cyclophosphamide and tamoxifen, is started. Which of the following mechanisms best explains the likely beneficial effect of tamoxifen in this patient?
A ) Competition with cytoplasmic estrogen receptors
B ) Enhancement of cyclophosphamide cytotoxic effect therapy
C ) Inhibition of residual estrogen synthesis by the ovaries and adrenal glands
D ) Retardation of tumor growth by its androgenic activity
E ) Stimulation of membrane-bound progestin receptors
36. Which of the following antimicrobial agents is most likely to be administered orally for the treatment of potentially serious systemic infections because of its predictable bioavailability?
A ) Amphotericin B
B ) Ciprofloxacin
C ) Gentamicin
D ) Polymyxin B
E ) Vancomycin
40. Which of the following drugs for maintenance therapy in patients with moderate to severe asthma also has positive cardiac inotropic effects, produces vasodilation, has diuretic action, and stimulates diaphragmatic contraction?
A ) Atropine
B ) Beclomethasone
C ) Dextromethorphan
D ) Propranolol
E ) Theophylline
42. A 32-year-old woman has a 10-year history of chronic paranoia, auditory hallucinations, and the belief that characters in television programs are talking directly to her. Drug therapy is most likely to directly involve which of the following neurotransmitter systems?
A ) Acetylcholine
B ) γ-Aminobutyric acid (GABA)
C ) Dopamine
D ) Glutamate
E ) Norepinephrine
27. A 72-year-old man comes to the physician because of an 8-month history of feeling light-headed when he stands up. Blood pressure is 130/85 mm Hg while supine and 94/64 mm Hg while standing. High-dose fludrocortisone therapy is started. After 5 days of treatment, laboratory studies are most likely to show which of the following changes?
Serum Urine
K+ Renin K+ excretion
A ) ↓ ↑ ↑
B ) ↓ ↑ ↓
C ) ↓ ↓ ↑
D ) ↑ ↑ ↓
E ) ↑ ↓ ↑
F ) ↑ ↓ ↓
46. A healthy 30-year-old man is participating in a study of the effects of a competitive inhibitor of endothelial nitric oxide synthase. After intravenous injection of the inhibitor, blood pressure immediately increases. Supplementation with which of the following amino acids is most appropriate to reverse this increase?
A ) Arginine
B ) Aspartic acid
C ) Glutamic acid
D ) Leucine
E ) Lysine
F ) Methionine
G ) Tyrosine
45. A bacterium harboring a 15,000-base pair (bp) plasmid that encodes resistance to tetracycline and ampicillin segregates mutants that lose resistance to either drug. Each independent mutant plasmid appears to increase in size by approximately 5200 bp. Which molecular event best explains these findings?
A ) Formation of plasmid concatemers
B ) Formation of pyrimidine dimers
C ) Homologous recombination
D ) Insertion of a transposon
E ) Slip-stranded DNA replication errors
thanks for even looking at the qs. plz send me the answers.
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saif
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| mjl1717
Forum Hero
Topics: 956
Posts: 5,452
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Ill take 2:
18) comp .with cytoplasmic estrogen receptors
36)ciprofloxacin
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Smell the coffee! "Is That an Osler move??"
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| NE
Forum Guru
Topics: 53
Posts: 504
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18- A
19-B
40- E
42-C
27-C
46-A
45-D
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| proctalgia
Forum Senior
Topics: 2
Posts: 209
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36 ciprofloxacin
Vancomycin needs to be given intravenously (IV) for systemic therapy since it does not cross through the intestinal lining. It is a large hydrophilic molecule which partitions poorly across the gastrointestinal mucosa. The only indication for oral vancomycin therapy is in the treatment of pseudomembranous colitis, where it must be given orally to reach the site of infection in the colon.
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| cd
Forum Elite
Topics: 21
Posts: 92
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42 is D, because all the descripition is psycotic, in psycotic glutamate will be increased, so drug therapy is directed against glutamate, correct me if i am wrong.
cd
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| jean robert
Forum Guru
Topics: 164
Posts: 675
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Hi what to do,
my answers are :
18-A
36-B
40-E
42-C
27-F
46-A
45-(I don t know the answer) i just pick A
Please, send the correct answers
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Great works are performed not by strength, but by perseverance.
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| oldschool
Forum Newbie
Topics: 0
Posts: 7
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mine are..
a
b
e
c
donno.. wats the sequence asked..
a
d
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keep the faith!
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| werther
Forum Senior
Topics: 11
Posts: 110
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Antipsychotic drugs mechanism of action is mainly blocking dopamine receptors so i think is dopamine.
in regard of the others, i will check it up.
I took last monday the NBME test and had all those questions in the set #1, it looks like they use always the same set of questions! or what?
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| me007
Forum Guru
Topics: 72
Posts: 803
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nobody answered A. for # 27.
27. A 72-year-old man comes to the physician because of an 8-month history of feeling light-headed when he stands up. Blood pressure is 130/85 mm Hg while supine and 94/64 mm Hg while standing. High-dose fludrocortisone therapy is started. After 5 days of treatment, laboratory studies are most likely to show which of the following changes?
Serum K+; Renin; Urine K+ excretion
A ) ↓ ↑ ↑
B ) ↓ ↑ ↓
C ) ↓ ↓ ↑
D ) ↑ ↑ ↓
E ) ↑ ↓ ↑
F ) ↑ ↓ ↓
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| shalini.ravi
Forum Senior
Topics: 17
Posts: 153
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why r the renin levels elevated? here the aldosterone levels rise so wont there be feedback inhi of renin? am kinda confused can anyone explain.i thought d main regulator of renin was a2
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mediocricity aint my style
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| me007
Forum Guru
Topics: 72
Posts: 803
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yes, renin is not elevated, C is correct, right?
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| shalini.ravi
Forum Senior
Topics: 17
Posts: 153
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yup am for c too...anyone else guys?
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mediocricity aint my style
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| Mikeland
Forum Senior
Topics: 24
Posts: 109
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on 27 I think the answer is A because renine is not regutated for steroid. Its release is stimulated by
1) sympathetic nerve activation (acting via b1-adrenoceptors)
2) renal artery hypotension (caused by systemic hypotension or renal artery stenosis)
3) decreased sodium delivery to the distal tubules of the kidney.
I have Na decreased at the distal tubules when I use steroid in this case or not?
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| sany
Forum Senior
Topics: 7
Posts: 120
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I go for C ...No.27
Reason: As of the treatment one can logically expect the effect of Aldosterone. Urine K excretion increases and the Serum K decreases.Concerning Serum Renin level..Aldosterone does not have a direct effect on Renin production...but by stimulating Sodium reabsorption aldosterone causes water retention viv a viz ...decrease in renin production.So the serum level of Renin decreases.
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sany
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| epica
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to nnl,
What do u think?
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| new_n_lost
Forum Hero
Topics: 654
Posts: 6,116
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18. A ) Competition with cytoplasmic estrogen receptors (MOA)
36. B ) Ciprofloxacin (is the Best Among Given)
40. E ) Theophylline (MOA)
42. C ) Dopamine ( someone wrote Glutamate if she was having a seizure then maybe)
27. C ) ↓ ↓ ↑ Synthetic Analog Of Aldosterone Know the Effects of Aldosteron on K,Renin thats Ans
46. A ) Arginine
45. Dont Know
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| epica
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Yes, agree w u.
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| lq2006
Forum Elite
Topics: 43
Posts: 382
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A
B
E
C
C
A
D
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| Addicudo
Forum Guru
Topics: 124
Posts: 615
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18. A ) Competition with cytoplasmic estrogen receptors (MOA)
36. B ) Ciprofloxacin 40. E ) Theophylline
42. C ) Dopamine
27. C ) ↓ ↓ ↑ Synthetic Analog Of Aldosterone(WEAK Analog)
46. A ) Arginine
45. D) Insertion of Transposon
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| goodies
Forum Junior
Topics: 19
Posts: 39
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hey guys, for people taking corticosteroids... what is the mineralocorticoid activity due to? according to goljan page 511, aldosterone is NOT increased, but it's due to "weak mineralocorticoid" activity. so what is it?
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| mildus
Forum Guru
Topics: 19
Posts: 614
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Glicocorticosteroids (beside other effects) also have certain mineralocorticoid activity, although it is much weaker than that of mineralocorticosteroids.
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