kiranmayi
Forum Guru
Topics: 237
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A patient comes to see you because he has been weak and falling down frequently. During the interview, you note that he is suspicious and irritable. On physical examination, you note that his skin is pale, his tarsal plates are pale, and he has a loss of vibration sense over his legs and trunk. His legs show a symmetric weakness with decreased deep tendon reflexes. The leading theory for the pathophysiology of this disorder relates to which of the following?
A. Anamolous insertion of even-chain fatty acids into membrane lipids
B. Anomalous insertion of odd-chain fatty acids into membrane lipids
C. Increased vitamin A intake
D. Lack of methylmalonyl CoA
E. Lack of propionyl CoA
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| sm
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the answer is E
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| krsma
Forum Elite
Topics: 40
Posts: 227
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can you give an explanation of the answer if you can just to help understand it better. Thanks :icon_bounce:
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| kiranmayi
Forum Guru
Topics: 237
Posts: 407
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Answer is B. Anomalous insertion of odd-chain fatty acids into membrane lipids
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| asmi
Forum Hero
Topics: 1043
Posts: 4,609
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can you explain it further ?
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| Malaysian
Forum Guru
Topics: 28
Posts: 778
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This condition is due to deficiency of vit. B12....hence the megaloblastic anaemia(the paleness) and the peripheral neuropathy.Vit.B12 cause peripheral neuropathy because they are used in the lipids meant for myelin in the nervous system.Vit B12 are needed for 2 major enzymes.....Homocysteine methyltransferase(SAM,Methionine)...defect in this pathway is the one causing the megaloblastic anaemia while the other enzyme methylmalonyl coa mutase for odd chain fatty acid metabolism....so deficinecy of this enzyme causes odd chain fatty acids to get incorporated in the myeline sheath
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| Idiopathic
Forum Guru
Topics: 19
Posts: 641
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Can someone tell me what tarsal plates are?
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| asmi
Forum Hero
Topics: 1043
Posts: 4,609
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they r in upper eyelids
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| usmleasr
Forum Guru
Topics: 105
Posts: 970
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good q just now seeing it...SCD of spinal cord
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