sitara101
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if a mother who is a carrier for sickle cell, wants to go to a high altitude region for a vacation, would u advise against it because it would affect her fetus? I had thought the answer would be yes, since at low oxygen tensions the sickle cell trait would show its effects.
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| po
Forum Elite
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so,it is no???how?
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| me007
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Fetus has HbF - not HbS - will not be affected by low O2 tension.
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| drbcshah
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yes But what about oxygen delivered to it when in womb- I mean What is effect of high altitude on a sickle cell trait carrier ( Who is also Pregnant )????
This is an interesting question
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| Ancylostoma
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Doctor guju(shah) has made a good point. I would think since there would be some sickling in the pregnant mother at low altitude, it would effect the fetus. Even though there is no sickling in the child, there is a less o2 to compete for between the two types of HB. This is my thought process, it could be wrong. Whats the answer sitara 101
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| me007
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In real life i would say, is it so nesessary being pregnant with sickle cell trait to go to high altitude just for fun?
From physio -
medium altitude - 2500 m - defined as area were there is no evidence of acute mountain sickness and no need to acclimatization
high altitude - 2500 - 5300m - body has to acclimatize
extreme altitude - 5300 - 8848 m - constant acclimatization is not possible
but q is - would it affect fetus.
If she will have complications related to ischemic damage, such a complications will might affect her fetus.
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| young_doc
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The increase in 2,3BPG seen in high altitudes should compensate for the low O2 tension in high altitude, therefore delivering O2 to the fetus. (And of course sickle cell does not affect a fetus)
So high altitude should have no effect.
The only plausible way that it would affect the fetus is if the mother gets a sickling crisis in the placenta or blood vessels leading to the placenta, which is rare, because sickling crisis only occurs in very small blood vessels.
My 2 cents.
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| Ancylostoma
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doesnt high altitude dcrease Po2 ? And doesnt po2 determine O2 saturation ?
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| vijay vegesna
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i have a doubt.this lady is a carrier for the sickle cell trait,but not affected by it.
so will she get sickle cell crisis if she goes to high altitude?please someone clarify my doubt.
increased 2,3 bpg compensates for the low o2 tesion at high altitudes.
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| new_n_lost
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Here r My 2 cents on the topic
Although the Fetus doesnt get affected by a sickling crisis but it is imperative that it shud be remmembered that pts with Sickle cell trait do tend to have complications on high altitude n therefore in a way might affect the fetus indirectly therefore we have to advise the mother not to take an unnecessary risk
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| kuka
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i agree with new n lost. Hb S has sticky patches on its surface which are adhesive when HbS is deoxygenated. thus patients with sickle cell disease tend to have thrombotic episodes when they become hypoxic or dehydrated. individual with sickle cell trait would probably develop some complications, depending on the altitude and period of time spent there. and that would be enough to harm the unborn.
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