paganini
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A person with cystic fibrosis develops osteomylitis. What organism is most likely responsible for the infection?
1)E. coli
2)Salmonella typhi
3)Staphylococcus aureus
4)Pseudomonas aeruginosa
3?
I read that patients with CF are resistant to S. typhi. The answer says is 2, I am confused.
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| macTT
Forum Senior
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3 your right,
Samonella still common in pts with Sickle cell. But MCC of all is STAPH
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| paganini
Forum Senior
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I never mentioned Sickle cell. This is a patient with cystic fibrosis.
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| paganini
Forum Senior
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Is nobody going to answer this?
Do someone have an idea?
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| muggingsadly
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For what its worth, S. aureus is a very common cause of osteomyelititis and has been linked to CF patients.
Cystic fibrosis mutates the receptor that Salmonella binds to in the GIT, thus giving resistance to Salmonella.
I'm not absolutely sure about this, but if i had to choose between 2 & 3, I would go with S. Aureus 
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| paganini
Forum Senior
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Thanks for your opinion
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| NE
Forum Guru
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why not pseudomonas?
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| jamdoc
Forum Elite
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pseudomonas causes lung infections in CF pt's, most C.C of O.Myelitis is S.aureus except in sicklers.
so i would go with Staph.aureus.
if anything is mentioned abt a nail stick etc then probably it is pseudomanas.
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| lq2006
Forum Elite
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It's Staphylococcus aureus
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| tompat
Forum Elite
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yah staph
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| SmokyWaters
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1)E. coli ... usually causes infection in hospital acquired/UTI/GM negative septic patient/open wound near perineum
2)Salmonella typhi .... usually in patients having old infarcts in bones....salmonella loves old places...as in sickle cell/thalassemia....they say sickle cell most of the times because the study that was carried out was done in SCD but its true for any old infarct...even the old aneurysms are also colonized by salmonella
3)Staphylococcus aureus ... 90% cases caused by staph even in SCD ....staph is the second in number....
4)Pseudomonas aeruginosa...osteochondritis in puncture wounds is common but requires OXYGENATION so not in closed osteo
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