gilbert
Forum Junior
Topics: 16
Posts: 45
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A 61-year-old woman has been treated for the past 10 years with warfarin anticoagulant therapy. Her prothrombin time (INR) has remained stable. Which of the following curves shows the most likely change in her prothrombin time following addition of cimetidine to her regimen?
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| aml
Forum Senior
Topics: 5
Posts: 121
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B
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| aml
Forum Senior
Topics: 5
Posts: 121
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MOST PROBABLY SYNERGISM
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| NE
Forum Guru
Topics: 53
Posts: 504
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B-cimetidine is a cytocrome (1A2) inhibitor so warfarin's metabolism will be decrease
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| vallia
Forum Guru
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B , cimetidine is P450 inhibitor
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| fox
Forum Guru
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what about omeprazole & amoxycillin? Are they inhibitors too?
FA says:
Inducers: quinidine/barbiturates/phenytoin/rifampicin/griseofulvin/carbamazepine
Inhibitors: Isoniazid/Sulfonamides/Cimetidine/Ketoconazole/Erthromycin/Grapefruit Juice.
Could someone add to the list if there are any omissions?
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| gilbert
Forum Junior
Topics: 16
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Why not A? Can someone explain? Thanks.
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| girl^interrupted
Forum Elite
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fox, the list is so long that it boggles the mind. I'm trying to work on the list by makin 3 columns, drugs metabolised by p450, inhibitors n inducers.
It has confused me for so long ,so I'm trying to make my own list of important drugs. Will post it here soon.
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| Dinie
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A shows an immediate effect. There should be some time gap for inhibition of Cyt P 450 action by cimetidine to occur.
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