neo335
Forum Elite
Topics: 39
Posts: 174
|
can any plz explain, why in the Diabetes Insipidus type, where we r having resistance to ADH action we r giving HCTZ n chlorthiazide.. these r diuretics , right.. so we wud be losing more wayer.. thats what w dont want to do right... thanking u in advance... 
neo
|
| star1
Forum Guru
Topics: 93
Posts: 827
|
in DI the plasma osmolality increase , we are given diuretic to decrease renal Na reabsortion
|
| ssrpk
Forum Fanatic
Topics: 154
Posts: 2,819
|
A good rule of thumb is ... patienst with SIADH and Diabetes Insipidus are euvolemic i.e. Normal Effective arterial blood volume! thts why normal physical examination and no signs of either dehydration or edema!
however plasma osmolality will change significantly!
Now the purpose of thiazides is that [which seem like a paradox], thiazides reduce the Na+Cl- reabsorption in the DCT, which therefore would evoke compensatory increase reabsorption in the proximal tubules! along with water! Now thnk thru it, in DI, you are'nt losing any salt, its only the loss of free water, therefore pharmacologically we envoke salt loss which will result in inc. reabsorption of both salt and water in the proximal tubules which is a normal compensation when ever pt. becomes salt deficient! In short salt rescues the free water!
___________________
life is guud
|
| neo335
Forum Elite
Topics: 39
Posts: 174
|
thank u both..that was a good explaination
neo
|
| star1
Forum Guru
Topics: 93
Posts: 827
|
good job ssrpk
|
|
| |
| | | | | |
Similar forum topics