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ETIN
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11/18/06 - 12:54 PM             #1

I dont understand why Thiazides and Loop Diuretics can have hyperuricemia as their S/E? Is there sum connection with da fact that both are sulfa type drugs?
disapproval

Leopard
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11/18/06 - 01:13 PM             #2

Loop diuretics and Thiazides are SECRETED into the PCT by Organic acid transporters.Uric acid is also secreted through the same transporter.So there is competive inhibition and retention of Uric acid .

Other organic acids which have same effect are
  1. Ketoacids
  2. Lactic acid
  3. Low dosages of Acetylsalicylic acid

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Slacker
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11/18/06 - 03:05 PM             #3

nice explain. where did u get it from, its not in Kaplangrin







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