virgola82
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Hi guys, sorry for my ignorance. Can anyone explain me why increasing the extracellular K leads to partial depolarization of the cell membrane?
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| Leopard
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Negativity present inside the cell is due to Efflux of K under the influence of Concentration gradient. If you increase ECF ,K level then this gradient is reduced -----------> Less K efflux-------------> Less negativity inside the cell ( Depolarization)
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| vallia
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agree, the K is not at equilibrium in resting condition( the equilibrium potential for K is 105 mv, and the membrane potential is 90mV), the net force of K is 105-90=15 mV and there is always an efflux of K ions through the ungated K channels. When outside K rise ,we have less efflux or even an influx of K ions which depolarise the cell.(make he inside more positive)
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| ssrpk
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hmmm, increasing extracellular K+ will also make the equilibrium potential of K+ more positive or less negative!
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